2024
Andrew Lombardo: ARHGAP18-ezrin functions as an autoregulatory module for RhoA in the assembly of distinct actin-based structures.
2021
Miller M, McDermitt D, Sauvanet C, Lombardo A, Zaman R, Bretscher A. The RabGAPs EPI64A and EPI64B regulate the apical structure of epithelial cells†. MBoC. 2021. doi: 10.1091/mbc.E21-05-0268
Zaman R, Lombardo A, Sauvanet C, Viswanatha R, Awad V, Bonomo L, McDermitt D, Bretscher A. Effector-mediated ERM activation locally inhibits RhoA activity to shape the apical cell domain. JCB. 2021. 220(6): e202007146.
2020
Gringas RM, Lwin KM, Miller AM, Bretscher A. Yeast Rgd3 is a phospho-regulated F-BAR-containing rhogap involved in the regulation of rho3 distribution and cell morphology. Mol Biol Cell. 2020. 31(23): 2570-2582. doi: 10.1092/mbc.E20-05-0288.
2018
Pelaseyed T, Bretscher A. Regulation of actin-based apical structures on epithelial cells. Journal of Cell Science. 2018. 131(21): jcs221853 doi: 10.1242/jcs.221853.
Shin M, van Leeuwen J, Boone C, Bretscher A. Yeast Aim21/Tda2 both regulates free actin by reducing barbed end assembly and forms a complex with Cap1/Cap2 to balance actin assembly between patches and cables.. Mol Biol Cell. 2018 Apr 15;29(8):923-936. doi: 10.1091/mbc.E17-10-0592. Epub 2018 Mar 30.
2017
Pelaseyed T, Viswanatha R, Sauvanet C, Filter JJ, Goldberg ML, Bretscher A. Ezrin activation by LOK phosphorylation involves a PIP2-dependent wedge mechanism.. Elife. 2017 Apr 21;6. pii: e22759. doi: 10.7554/eLife.22759.
2016
Lwin K, Li D, Bretscher A. Kinesin-related Smy1 enhances the Rab-dependent association of myosin-V with secretory cargo. Mol Biol Cell. 2016 Aug 1;27(15):2450-62. doi: 10.1091/mbc.E16-03-0185.
2015
Sauvanet C, Wayt J, Pelaseyed T, Bretscher A. Structure, regulation, and functional diversity of microvilli on the apical domain of epithelial cells. Annu Rev Cell Dev Biol. 2015;31:593-621. doi: 10.1146/annurev-cellbio-100814-125234.
Sauvanet C, Garbett D, Bretscher A. The function and dynamics of the apical scaffolding protein E3KARP are regulated by cell-cycle phosphorylation.. Mol Biol Cell. 2015 Oct 15;26(20):3615-27. doi: 10.1091/mbc.E15-07-0498. Epub 2015 Aug 26.
Donovan K, Bretscher A. Tracking individual secretory vesicles during exocytosis reveals an ordered and regulated process. J Cell Biol. 2015 Jul 13;210(2):181-9.
Donovan K, Bretscher A. Head-to-tail regulation is critical for the in vivo function of myosin V. J Cell Biol. 2015 May 4;209(3)359-365.
2014
Xu L, Bretscher A. Rapid Glucose Depletion Immobilizes Active Myosin V on Stabilized Actin Cables. Curr Biol. 2014 Oct 8; S0960-9822(14)01137-3.
Garbett D, Bretscher A. The surprising dynamics of scaffolding proteins. Mol Biol Cell. 2014 Aug 15;25(16):2315-9.
Wayt J, Bretscher A. Cordon Bleu serves as a platform at the basal region of microvilli where it regulates microvillar length through its WH2 domains. Mol Biol Cell. 2014 Jul 16.
Viswanatha R, Bretscher A, Garbett D. Dynamics of ezrin and EBP50 in regulating microvilli on the apical aspect of epithelial cells. Biochem Soc Trans. 2014 Feb 1;42(1):189-94.
2013
Viswanatha R, Wayt J, Ohouo PY, Smolka MB, Bretscher A. Interactome analysis reveals ezrin can adopt multiple conformational states. J Biol Chem. 2013 Dec 6;288(49):35437-51.
Bretscher, A. Deconstructing formin-dependent actin cable assembly. PNAS 2013 Nov 19; 110(47):18744-5
Chernyakov I, Santiago-Tirado F, Bretscher A. Active Segregation of Yeast Mitochondria by Myo2 Is Essential and Mediated by Mmr1 and Ypt11. Curr Biol. 2013 Sep 4; 23:(18) 1818–1824
Garbett, D., Sauvanet, C., Viswanatha, R. & Bretscher, A. The tails of the scaffolding proteins EBP50 and E3KARP regulate their localization and dynamics. Mol Biol Cell 2013 Aug 20; 24, 3381-3392.
Bretscher A. Magazine or journal–what is the difference? The role of the monitoring editor. Mol Biol Cell. 2013 Apr;24(7):887-9
2012
Viswanatha R, Ohouo PY, Smolka MB, Bretscher A. Local phosphocycling mediated by LOK/SLK restricts ezrin function to the apical aspect of epithelial cells. J Cell Biol. 2012 Dec 10;199(6):969-84
Donovan KW, Bretscher A. Myosin-V is activated by binding secretory cargo and released in coordination with Rab/exocyst function. Dev Cell. 2012 Oct 16;23(4):769-81
Garbett D, Bretscher A. PDZ interactions regulate rapid turnover of the scaffolding protein EBP50 in microvilli. J Cell Biol. 2012 Jul 23;198(2):195-203
Mi-Mi L, Votra S, Kemphues K, Bretscher A, Pruyne D. J. Z-line formins promote contractile lattice growth and maintenance in striated muscles of C. elegans. Cell Biol. 2012 Jul 9;198(1):87-102
Sher I, Hanemann CO, Karplus PA, Bretscher A. The tumor suppressor merlin controls growth in its open state, and phosphorylation converts it to a less-active more-closed state. Dev Cell. 2012 Apr 17;22(4):703-5
Hokanson DE, Bretscher AP. EPI64 interacts with Slp1/JFC1 to coordinate Rab8a and Arf6 membrane trafficking. Mol Biol Cell.2012 Feb;23(4):701-15
Liu W, Santiago-Tirado FH, Bretscher A. Yeast formin Bni1p has multiple localization regions that function in polarized growth and spindle orientation. Mol Biol Cell. 2012 Feb;23(3):412-22
2011
Santiago-Tirado FH, Bretscher A. Membrane-trafficking sorting hubs: cooperation between PI4P and small GTPases at the trans-Golgi network. Trends Cell Biol. 2011 Sep;21(9):515-25
Santiago-Tirado FH, Legesse-Miller A, Schott D, Bretscher A. PI4P and Rab inputs collaborate in myosin-V-dependent transport of secretory compartments in yeast. Dev Cell. 2011 Jan 18;20(1):47-59
LaLonde DP, Bretscher A. The UBX protein SAKS1 negatively regulates endoplasmic reticulum-associated degradation and p97-dependent degradation. J Biol Chem. 2011 Feb 11;286(6):4892-901
2010
Garbett D, LaLonde DP, Bretscher A. The scaffolding protein EBP50 regulates microvillar assembly in a phosphorylation-dependent manner. J Cell Biol. 2010 Oct 18;191(2):397-413
Fehon RG, McClatchey AI, Bretscher A. Organizing the cell cortex: the role of ERM proteins. Nat Rev Mol Cell Biol. 2010 Apr;11(4):276-87
LaLonde DP, Garbett D, Bretscher A. A regulated complex of the scaffolding proteins PDZK1 and EBP50 with ezrin contribute to microvillar organization. Mol Biol Cell. 2010 May 1;21(9):1519-29
Gao L, Liu W, Bretscher A. The yeast formin Bnr1p has two localization regions that show spatially and temporally distinct association with septin structures. Mol Biol Cell. 2010 Apr 1;21(7):1253-62
2009
Bretscher A. Epithelial polarity: dual Lkb1 pathways regulate apical microvilli. Dev Cell. 2009 Apr;16(4):491-2
IIA. Ilani T, Vasiliver-Shamis G, Vardhana S, Bretscher A, Dustin ML. T cell antigen receptor signaling and immunological synapse stability require myosin. Nat Immunol. 2009 May;10(5):531-9
Gao L, Bretscher A .Polarized growth in budding yeast in the absence of a localized formin. Mol Biol Cell. 2009 May;20(10):2540-8
LaLonde DP, Bretscher A. The scaffold protein PDZK1 undergoes a head-to-tail intramolecular association that negatively regulates its interaction with EBP50. Biochemistry. 2009 Mar 17;48(10):2261-71
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